UCL Institute of Neurology, Department of Brain Repair and Rehabilitation (F82)![]() The Department of Brain Repair and Rehabilitation aims to understand mechanisms underlying neurological diseases and develop new treatments for patients with neurological conditions. The Department brings together several different areas of basic and clinical neuroscience, encouraging collaboration both within its various teams as well as with other departments across the Institute of Neurology, the National Hospital for Neurology & Neurosurgery, the Faculty of Brain Sciences and UCL at large. FOR ALL QUERIES PLEASE USE THE CONTACT TABS FOUND IN EACH OF THE INDIVIDUAL COURSES/CONFERENCES AND PRODUCTS, PLEASE ONLY CONTACT THE ONLINE STORE DIRECTLY IF YOU ARE EXPERIENCING PAYMENT DIFFICULTIES.UCL Institute of Neurology, Department of Brain Repair and Rehabilitation (F82)F82 UCL Centre for Neurorehabilitation Monthly Seminar 06/11/2025DescriptionDysautonomia - the key to understanding chronic fatigue Professor Manoj Sivan, University of Leeds Dysautonomia, or autonomic dysfunction, is a well-recognised phenomenon frequently observed in conditions associated with chronic fatigue—particularly in neurological disorders and long-term post-infectious syndromes such as Long COVID, ME/CFS (Myalgic Encephalomyelitis/Chronic Fatigue Syndrome), and Fibromyalgia. A defining feature of these conditions is post-exertional malaise, a key symptom of dysautonomia. This dysfunction plays a central role in both the development and persistence of symptoms in these long-term conditions. Despite robust documentation in the scientific literature, significant stigma and scepticism still surround these syndromes. In this interactive talk, we will explore diagnostic approaches for dysautonomia, including the NASA Lean Test, drawing on insights from our clinical experience and findings from the NIHR LOCOMOTION study. We will examine the adapted Autonomic Profile (aAP)—a home-based test co-developed with the UCL Autonomic Unit. We will also discuss the role of heart rate variability (HRV) as an indirect marker of autonomic dysfunction, with particular reference to the HEARTLOC study, which investigates HRV biofeedback using diaphragmatic breathing interventions. Additionally, we will discuss medical and rehabilitation strategies for managing dysautonomia in the context of chronic fatigue and post-exertional malaise. The goal of this session is to increase awareness of dysautonomia and advocate for compassionate, evidence-based care for those affected. Bio contd. in ‘more info’ tab.
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